If transactions invoke MQ APIs, an MQ XA resource definition must be associated with the region to enable CICS to connect to the required MQ queue manager to which the APIs will be targeted. An MQ XA resource definition can be associated with a region at either the SIT or region startup file level. When specified in both the SIT and region start-up file, the region startup file takes precedence. To associate an MQ XA resource definition with a SIT:
You must cold-start the region for the changes to take effect.