You can configure iFileshare to offer enhanced availability for mission critical files by configuring a high availability group, consisting of a primary iFileshare server and a number of stand-by servers. (This type of configuration currently only supports having one stand--by server; the ability for more stand-by servers is planned.)
Files critical to your application can be replicated from a primary server to the stand-by servers. Should the primary server fail, you have up-to-date data (minus any in-flight transactions) available.
To reduce the complexity and increase the stability of an iFileshare high availability group, it is recommended that each region is configured as a dedicated iFileshare server. If other Enterprise Server work is hosted within the group, the setup must be consistent on each server, so that in the event of a fail-over, the non-Fileshare work can be continued on the new primary server.