.NET COBOL applications running on a 64-bit platform can use either the 32-bit or the 64-bit Common Language Runtime (CLR).
The default setting for the project's property Platform Target is AnyCPU. This means that on a 64-bit computer the 64-bit CLR is used and on a 32-bit computer the 32-bit CLR is used. You can also specify in the Platform Target that a specific bitism should be used such as x86 for 32-bit or x64 for 64-bit.
Most COBOL programs can run on 64-bit systems without recompilation. However, there are some cases where you need to ensure that COBOL pointer items in your application are allocated as 64 bits in size rather than the default of 32 bits. To do this you set the project property Generate 64-bit Pointers.
You need to generate 64-bit pointers when:
If your application uses native COBOL code, and you need to execute that code on a 64-bit CLR, you need to ensure it is recompiled to target the appropriate 64-bit processor.